Most of the causes are unknown, some are due to environmental or inheriting factors…

A. Environmental factors

  1.  Viral infection – e.g. German measles.
  2. Drug effect – e.g. Anti-convulsion, cytotoxic drugs, steroid etc.
  3. Exposure to X-ray radiation during pregnancy
  4. Nutritional inbalance – caused by repeated vomiting and poor appetite during pregnancy.

B. Inheriting factors

Formed by abnormal factors, cells or chromosomes. . If one of the parents is a cleft lip/palate patient, or the parents have on affected child, the occurrence ratio could be as high as 1:20; if both parents are cleft patients or they already have two affected children, the occurrence ration is 1:4.

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